조효소 F420

3. 기능

조효소 F₄₂₀은 조효소 F₄₂₀ 수소화효소, 5,10-메틸렌테트라하이드로메탄opterin 환원효소, 메틸렌테트라하이드로메탄opterin 탈수소효소의 기질이다.^[6][7][8]

F₄₂₀은 다양한 효소에서 기질 산화(탈수소화) 또는 기질 환원에 사용되며, 고세균과 세균을 포함한 다양한 생물에서 메테인 생성, 항생제 생합성, DNA 복구 및 항결핵 약물 활성화 등 산화 환원 반응에서 중요한 역할을 한다. F₄₂₀의 수소화물 전달 능력은 특정 생화학 경로에 최적화된 낮은 산화 환원 전위 덕분이다.^{[5][9][10][11]}

3. 1. 주요 기능

3. 2. F420 의존성 효소 반응

3. 3. 생물학적 역할

4. 임상적 의의

델라마니드는 다른 항결핵제와 함께 다제내성 결핵(MDRTB) 치료에 사용되는 약물이다. 미코박테리아 내에서 데아자플라빈 의존성 니트로환원효소(Ddn)에 의해 활성화되는데, 이 효소는 디하이드로-F₄₂₀(환원 형태)을 사용한다. 활성화된 약물 형태는 반응성이 높아 세포벽 합성 효소(예: DprE2)를 공격한다. 프레토마니드도 같은 방식으로 작용한다. 이 두 약물에 내성을 보이는 임상 분리 균주는 F₄₂₀ 생합성 경로에 돌연변이를 보이는 경향이 있다.^[12]

참조

_[1] 논문 Redox-driven proton translocation in methanogenic Archaea 2002-09
_[2] 논문 Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria 2010-11
_[3] 논문 The methanogenic redox cofactor F(420) is widely synthesized by aerobic soil bacteria. 2017-01
_[4] 논문 The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes 2009-07
_[5] 논문 Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea 2021-09-08
_[6] 논문 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization 1987-07
_[7] 논문 Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure 2003-10
_[8] 논문 Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri 1991-09
_[9] 논문 Coenzyme F 420 -Dependent Glucose-6-Phosphate Dehydrogenase-Coupled Polyglutamylation of Coenzyme F 420 in Mycobacteria 2018-12
_[10] 논문 Molecular Insights into the Biosynthesis of the F420 Coenzyme 2008-04
_[11] 논문 Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea 2021-09-08
_[12] 논문 DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid 2023-06-28
_[13] 논문 Redox-driven proton translocation in methanogenic Archaea 2002
_[14] 논문 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization 1987
_[15] 논문 Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure 2003
_[16] 논문 Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri 1991
_[17] 논문 Redox-driven proton translocation in methanogenic Archaea https://archive.org/[...] 2002-09
_[18] 논문 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization 1987-07
_[19] 논문 Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure 2003-10
_[20] 논문 Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri 1991-09
_[21] 논문 Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria https://archive.org/[...] 2010-11
_[22] 논문 The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes 2009-07